Take Your Pic: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic
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Enhancement of Bistability in Spinal Motoneurons In Vivo by the Noradrenergic a1 Agonist Methoxamine
[PDF] [Full Text] [Abstract] , November 1, 2006; 96 (5): 2200-2206. J Neurophysiol S. M. Jones and R. H. Lee Fast Amplification of Dynamic Synaptic Inputs in Spinal Motoneurons In Vivo [PDF] [Full Text] [Abstract] , February 1, 2007; 97 (2): 1236-1246. J Neurophysiol X. Li, K. Murray, P. J. Harvey, E. W. Ballou and D. J. Bennett Without Chronic Spinal Cord Injury Serotonin Facilitates a Per...
متن کاملTake Your PIC: motoneuronal persistent inward currents may be somatic as well as dendritic. focus on "facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons".
Inputs to motoneurons can be amplified and prolonged by noninactivating conductances mediating “persistent inward currents” or PICs. These currents, first identified by Schwindt and Crill (1977), are generated through voltage-dependent channels that have been thought to be confined to the membrane of the motoneuronal dendritic tree (see Heckman et al. 2003). In this issue of the Journal of Neur...
متن کاملSuppressing the excitability of spinal motoneurons by extracellularly applied electrical fields: insights from computer simulations.
The effect of extracellularly applied electrical fields on neuronal excitability and firing behavior is attributed to the interaction between neuronal morphology and the spatial distribution and level of differential polarization induced by the applied field in different elements of the neuron. The presence of voltage-gated ion channels that mediate persistent inward currents (PICs) on the dend...
متن کاملComputational estimation of the distribution of L-type Ca(2+) channels in motoneurons based on variable threshold of activation of persistent inward currents.
In the presence of neuromodulators such as serotonin and noradrenaline, motoneurons exhibit persistent inward currents (PICs) that serve to amplify synaptic inputs. A major component of these PICs is mediated by L-type Ca(2+) channels. Estimates based on electrophysiological studies indicate that these channels are located on the dendrites, but immunohistochemical studies of their precise distr...
متن کاملComputational Estimation of the Distribution of L-type Ca Channels in Motoneurons Based on Variable Threshold of Activation of Persistent Inward Currents
Bui, T. V, M. Ter-Mikaelian, D. Bedrossian, and P. K. Rose. Computational estimation of the distribution of L-type Ca channels in motoneurons based on variable threshold of activation of persistent inward currents. J Neurophysiol 95: 225–241, 2006; doi:10.1152/jn.00646.2005. In the presence of neuromodulators such as serotonin and noradrenaline, motoneurons exhibit persistent inward currents (P...
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